Sufferers usually report varied signs after restoration from acute COVID-19. Earlier research on post-COVID-19 situation haven’t corrected for the prevalence and severity of those widespread signs earlier than COVID-19 and in populations with out SARS-CoV-2 an infection. We aimed to analyse the character, prevalence, and severity of long-term signs associated to COVID-19, whereas correcting for signs current earlier than SARS-CoV-2 an infection and controlling for the symptom dynamics within the inhabitants with out an infection.


This research is predicated on knowledge collected inside Lifelines, a multidisciplinary, potential, population-based, observational cohort research analyzing the well being and health-related behaviours of individuals residing within the north of the Netherlands. All Lifelines contributors aged 18 years or older acquired invites to digital COVID-19 questionnaires. Longitudinal dynamics of 23 somatic signs surrounding COVID-19 diagnoses (because of SARS-CoV-2 alpha [B.1.1.7] variant or earlier variants) had been assessed utilizing 24 repeated measurements between March 31, 2020, and Aug 2, 2021. Individuals with COVID-19 (a constructive SARS-CoV-2 take a look at or a doctor’s analysis of COVID-19) had been matched by age, intercourse, and time to COVID-19-negative controls. We recorded symptom severity earlier than and after COVID-19 in contributors with COVID-19 and in contrast that with matched controls.


76 422 contributors (imply age 53·7 years [SD 12·9], 46 329 [60·8%] had been feminine) accomplished a complete of 883 973 questionnaires. Of those, 4231 (5·5%) contributors had COVID-19 and had been matched to 8462 controls. Persistent signs in COVID-19-positive contributors at 90–150 days after COVID-19 in contrast with earlier than COVID-19 and in contrast with matched controls included chest ache, difficulties with respiration, ache when respiration, painful muscle tissues, ageusia or anosmia, tingling extremities, lump in throat, feeling cold and hot alternately, heavy arms or legs, and basic tiredness. In 12·7% of sufferers, these signs may very well be attributed to COVID-19, as 381 (21·4%) of 1782 COVID-19-positive contributors versus 361 (8·7%) of 4130 COVID-19-negative controls had not less than one in every of these core signs considerably elevated to not less than reasonable severity at 90–150 days after COVID-19 analysis or matched timepoint.


To our data, that is the primary research to report the character and prevalence of post-COVID-19 situation, whereas correcting for particular person signs current earlier than COVID-19 and the symptom dynamics within the inhabitants with out SARS-CoV-2 an infection through the pandemic. Additional analysis that distinguishes potential mechanisms driving post-COVID-19-related symptomatology is required.


ZonMw; Dutch Ministry of Well being, Welfare, and Sport; Dutch Ministry of Financial Affairs; College Medical Heart Groningen, College of Groningen; Provinces of Drenthe, Friesland, and Groningen.


After restoration from acute COVID-19, a considerable proportion of sufferers proceed to expertise signs of a bodily, psychological, or cognitive nature.


How and why sufferers made lengthy COVID.